The Importance of Bioimaging
Bioimaging plays a vital role in both research and clinical practice, which makes it possible to observe and study biological processes from the cellular and subcellular level to small animals. By using specific molecular probes or contrast agents, bioimaging technology can detect and characterize early-stage disease and provide a rapid method for monitoring response to treatment. Molecular imaging modes include optical imaging, radionuclide-based imaging, MRI (magnetic resonance imaging), PAI (photoacoustic Imaging), CT (computed tomography) and multimodal imaging.
Accelerate Research and Practice of Graphene in Bioimaging
Graphene and its derivatives can be easily functionalized with small molecule dyes, polymers, nanoparticles, drugs or biomolecules due to its multi-functional surface functionalization and ultra-high surface area, so as to be suitable for different biological imaging applications of graphene-based nanomaterials. For example, GO/rGO is functionalized with dye, QD or GNC has been widely used in FL imaging research. Due to its inherent photoluminescence properties, GQD can be used as a photoluminescence probe for FL imaging. In vivo PET imaging can be performed using 64Cu-labeled nGO-PEG. NGO conjugated to trastuzumab can be used for in vivo targeting and SPECT imaging.
Figure 1. Sinoporphyrin sodium (DVDMS) loaded GO for enhanced FL imaging. (Yan X, et al. 2015)
Figure 2. Schematic of the setup used for TPFI of N-GQDs in tissue phantom with different thickness. (Liu Q, et al. 2013)
Alfa Chemistry focuses on the research and development of graphene. Alfa Chemistry not only provides a variety of products suitable for bioimaging research, but also has graphene functionalization technology to produce customized graphene for bioimaging. All of the above are of great significance to the development of scientific research, clinical applications and cancer treatment.
What Can We Do?
- We provide downstream companies with graphene and other carbon materials suitable for bioimaging research.
- We offer custom services to develop graphene products for bioimagining.
- We set up large-scale graphene production lines for entrusted customers, provide customized graphene technical solutions and processes, and design complete graphene and carbon material production lines for bioimaging.
Alfa Chemistry Solutions for Bioimaging
Products
Services
Technology and Instrument Platform
Graphene modification, graphene quantum dots modification and other technologies.
SEM,TEM, AFM, Raman spectroscopy, XPS, ICP-OES, ICP-MS, EDS and other detection platforms.
Workflow
References
- Lin J, et al. (2016). “Graphene-Based Nanomaterials for Bioimaging.” Advanced Drug Delivery Reviews. 105, 242-254.
- Yan X, et al. (2015). “Enhanced Fluorescence Imaging Guided Photodynamic Therapy of Sinoporphyrin Sodium Loaded Graphene Oxide.” Biomaterials. 42, 94-102.
- Liu Q, et al. (2013). “Strong Two-photon-induced Fluorescence from Photostable, Biocompatible Nitrogen-doped Graphene Quantum Dots for Cellular and Deep-tissue Imaging.” Nano Lett. 13(6), 2436-2441.
