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Tissue engineering is the field of science that reproduces or regenerates damaged tissues or entire organs. To achieve its goals, it uses a combination of cells, engineered scaffolds and bioactive molecules to assemble functional constructs that restore, maintain or improve tissue function. Tissue engineering has the potential to reconstruct and replace defective body parts through advances in the medical field.
Graphene and graphene oxide (GO) are 2D materials with a large surface area that can provide as sufficient substrates for cell interaction and can carry many biomolecules, including DNA, enzymes, proteins or peptides through covalent or non-covalent interactions. In addition, their excellent mechanical and electrical properties can enhance the mechanical strength of tissue substitutes and apply electrical signals. Therefore, graphene and GO are excellent candidates for tissue engineering.
Figure 1. The overall tissue engineering applications of graphene and GO based on their properties. (Shang L. R, et al. 2019)
Researchers have used various methods, such as coating, hydrogel mixing, wet/dry spinning procedures, and 3D printing to prepare two-dimensional or three-dimensional graphene-based materials. For example, when a layer of graphene is covered on the surface of SiO2, it can promote the proliferation of human bone marrow mesenchymal stem cells. In addition, graphene combined with other materials (such as poly(L-lysine)) can significantly reduce its resistance and stimulate neuronal adhesion and neurite growth.
Figure 2. CSMA/PECA/GO hybrid scaffold for cartilage tissue engineering. (Liao J, et al. 2015)
The R&D team of Alfa Chemistry focuses on the development of graphene applications. We have a variety of graphene products suitable for tissue engineering research. At the same time, we also have a variety of graphene technologies, such as graphene functionalization and graphene transfer, to support the research and development of graphene in tissue engineering.
Graphene modification, graphene transfer and other technologies.
SEM,TEM, AFM, Raman spectroscopy, XPS, ICP-OES, ICP-MS, EDS and other detection platforms.